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خاصیت ضد مالاریایی گونه گیاهی سهرو(Boerhavia Elegans)

    The dichloromethane fraction of three extracts revealed stronger anti-plasmodial activity than the total extracts.

    Abstract

    Background

    There is an urgent need to identify new anti-malarial drug targets for both prophylaxis and chemotherapy, due to the increasing problem of drug resistance to malaria parasites.

    Results

    Of 10 plant species assayed, three species: Boerhavia elegans (Choisy), Solanum surattense (Burm.) showed promising anti-plasmodial activity in vitro (IC50 ≤ 50 μg/ml) and in vivo with no toxicity.f.

     

    2010 Ramazani et al; licensee BioMed Central Ltd

    . Crude ethanolic extracts showed good anti-plasmodial activity were further fractionated by partitioning in water and dichloromethane.) and Prosopis juliflora (Sw.

    Methods

    Ten plants found in Iran were selected by ethnobotanical survey of medicinal plants. In the present study, the aim was to discover novel, effective plant-based extracts for the activity against malaria. The anti-plasmodial activity of the extracts was also assessed in the 4-day suppressive anti-malarial assay in mice inoculated with Plasmodium berghei (ANKA strain). The crude ethanolic extracts were tested for in vitro anti-plasmodial activity against two strains of Plasmodium falciparum: K1 (chloroquine-resistant strain) and CY27 (chloroquine-sensitive strain), using the parasite lactate dehydrogenase (pLDH) assay
    این مطلب تا کنون 66 بار بازدید شده است.
    ارسال شده در تاریخ سه شنبه 3 دي 1392 [ گزارش پست ]

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آمار امروز دوشنبه 29 آبان 1396

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